Figure 2.
Representative fluorescence images of anti-t-PA-labeled arteries with luminal clot.10,40 A – clot treated with rt-PA (3.9 ± 2.1 μg/mL) and Definity® microbubbles (0.38 ± 0.21 μL/mL) in flowing porcine plasma, with ultrasound exposure (120-kHz continuous wave at a 0.44 MPa peak-to-peak pressure amplitude). B – clot treated with rt-PA only. Note that although both arteries display abundant autofluorescence, the ultrasound-treated artery does not demonstrate enhanced rt-PA penetration into the arterial tissue.