Table 3.
Comparisons of fatty acid elongation and desaturation in brain anterior cingulate cortex (BA 24) region between patients with MDD/BPD and control subjects.
| Ratio | Control | MDD/BPD | P* |
|---|---|---|---|
| n family | |||
| 16:0/14:0 | 23.59 ± 4.11† | 21.93 ± 3.45 | 0.272 |
| 18:0/16:0 | 0.76 ± 0.07 | 0.84 ± 0.11 | 0.037 |
| n-3 family | |||
| 20:5/18:3 | 0.31 ± 0.07 | 0.32 ± 0.09 | 0.760 |
| 22:5/20:5 | 0.73 ± 0.31 | 0.73 ± 0.59 | 0.983 |
| 22:6/22:5 | 21.32 ± 6.22 | 19.90 ± 5.45 | 0.540 |
| 22:6/18:3 | 4.83 ± 2.73 | 3.65 ± 2.63 | 0.288 |
| n-6 family | |||
| 20:3/18:2 | 1.03 ± 0.27 | 1.49 ± 0.58 | 0.023 |
| 20:4/20:3 | 9.02 ± 2.19 | 7.96 ± 1.49 | 0.160 |
| 20:4/18:2 | 9.18 ± 3.15 | 11.39 ± 3.56 | 0.111 |
| 22:4/20:4 | 0.17 ± 0.05 | 0.16 ± 0.04 | 0.473 |
| n-7 family | |||
| 18:1/16:1 | 6.04 ± 1.12 | 6.58 ± 0.96 | 0.198 |
| n-9 family | |||
| 18:1/18:0 | 1.35 ± 0.24 | 1.36 ± 0.22 | 0.899 |
| 20:1/18:1 | 0.023 ± 0.004 | 0.023 ± 0.004 | 0.887 |
| n-6/n-3 families | |||
| 18:2n-6/18:3n-3 | 0.64 ± 0.36 | 0.41 ± 0.20 | 0.058 |
| 20:4n-6/20:5n-3 | 16.98 ± 6.96 | 14.58 ± 6.52 | 0.384 |
| 20:4n-6/22:6n-3 | 1.16 ± 0.21 | 1.38 ± 0.30 | 0.048 |
| total n-6/total n-3 | 1.17 ± 0.14 | 1.25 ± 0.11 | 0.154 |
*
Statistical analysis (p values) was made between control and MDD/BPD (major depressive disorder and bipolar disorder) groups using a two-tailed unpaired t-test.
†
Each ratio represents mean and standard deviation.