TABLE 5.
Summary of the Literature
| Resistance to |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Investigator | Time period |
Biological source |
Name of substance |
Biological assay system |
Heat | Try- psin |
Chymo- trypsin |
Neuro- aminidase |
Response organ/ species |
Purification (%) |
Mr* |
| Blomqvist | 1957 | NbReL† | in vivo: NR | ||||||||
| LaBrecque | 1975–1987 | WRL-ReRL | HSS | in vitro: HTC cells | + | − | − | + | Yes/No | 110,000 | 14,000–15,000 |
| in vivo: 40% HeR | |||||||||||
| Hatase | 1979 | NL | in vitro: L-929 fibroblast | − | − | 30,000 | |||||
| in vivo: N and 34% HeR | |||||||||||
| Starzl | 1979 | ReL from 70% He dog | in vivo: dog with portacaval shunt | Yes | |||||||
| Goldberg | 1980–1985 | ReL from 70% He rat | Hepato-poietin | in vivo: NR | + | − | − | + | Yes/No | 13,000 | 38,000 |
| Terblanche | 1980 | Re dog L | in vivo: NR | ||||||||
| Francavilla | 1984–1985 | WRL | HSS | in vivo: 40% HeR | + | − | − | + | Yes/No | 38,000 | 15,000–50,000 |
| Schwarz | 1985 | ReL from 70% He R and pig | in vivo: 34% He female R and WR | + | No | 14,000–25,000 | |||||
| in vitro: hepatocyte cells | |||||||||||
| Lieberman | 1984 | Mouse plasma membrane | in vitro: NR-6 line fibroblast | − | + | − | − | ||||
| Fleig | 1986 | ReL from 60% He rabbit | in vivo: NR | − | − | ||||||
*
Determined by SDS-PAGE.
†
L, liver; N, normal; Nb, newborn; R, rat; Re, regenerating; He, hepatectomized; W, weanling.