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. Author manuscript; available in PMC: 2010 Oct 15.
Published in final edited form as: Biochim Biophys Acta. 2007 Nov 29;1778(2):454–465. doi: 10.1016/j.bbamem.2007.11.010

Fig. 1. Model of Mg·ATP-bound form of wild-type nucleotide binding site 1 of human MRP1.

Fig. 1

The nucleotide binding domain 1 (NBD1, 643-855) of human MRP1 was modeled based on the crystal structure of Mg·ATP-bound form of wild-type MRP1-NBD1 [30], whereas the NBD2 was modeled using the MJ0796-E171Q homodimer [17] as a template. The gray ribbon indicates the residues from NBD1, whereas the green ribbon represents the residues from NBD2. The gray sticks on the gray ribbon represent S685 in Walker A motif and D792 in Walker B motif. ATP is shown in stick representation. Red indicates oxygen atom; blue, nitrogen; yellow, phosphorus; cyan, Mg++ ion.