. Author manuscript; available in PMC: 2010 Oct 15.

Published in final edited form as: Biochim Biophys Acta. 2007 Nov 29;1778(2):454–465. doi: 10.1016/j.bbamem.2007.11.010

Table 1.

K_m (Mg·ATP) and V_max (LTC₄) Values of wild-type and mutant MRP1s.

	V_max (pmol/mg/min)^*	K_m (μM)^*
MRP1	164.0 ± 7.0	59.0 ± 2.2
S685T	330.7 ± 8.8	143.0 ± 8.2
S685D	65.3 ± 1.2	249.3 ± 6.3
D792S	79.3 ± 2.1	245.3 ± 8.2
S685D/D792S	99.0 ± 2.9	151.3 ± 6.8

K_m (Mg·ATP) and V_max (LTC₄) values for wild-type, S685T, S685D, D792S and S685D/D792S (n = 3) were derived from the corresponding Michaelis-Menten curves shown in Figure 6. The P value for comparison of K_m (Mg·ATP) of wild-type versus S685T is 0.0001 and, therefore, the P values for other mutants must be at most 0.0001.