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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Exp Gerontol. 2009 Aug 21;45(1):57–63. doi: 10.1016/j.exger.2009.08.003

Figure 2. Differentially-expressed proteins in Aβ-stimulated or not stimulated PBMC's of an AD patient.

Figure 2

Proteins from PBMC's cultured without Aβ were labeled with Cy3 (panel A), those cultured with Aβ were labeled with Cy5 (panel B), and both were examined by 2D-DIGE electrophoresis. Protein spots showing significant changes of more than 2.5-fold are shown. Proteins showing a decreased expression after incubation with Aβ are labeled red and those showing an increased expression after incubation are labeled blue. There were 8 spots showing at least 2.5-fold change in protein expression, five of them showing an increased expression upon Aβ treatment and 3 spots (red) showing a decreased expression (panels C and D). Although the proteins have not yet been identified, the observed characteristic spot pattern may be due to a shift in post-translational modification of these proteins.