Table 1.

Average fraction disorder (as a percentage) present in domain footprint (F) and interaction interface (I), according to the Disopred2, FoldUnfold, and VSL2 prediction methods. Data are shown for all families in the dataset and selected subsets

Family description	Number of families	Disopred2		FoldUnfold		VSL2
		F	I	F	I	F	I
All families	1364	6.1	4.4	11.4	9.6	18.2	15.7
1DDIa	611	7.7	5.8	13.5	11.8	21.5	18.7
>1DDI	753	4.7	3.4	9.8	7.9	15.6	13.2
>8DDI	61	3.1	2.1	9.4	7.8	13.6	11.4
Promiscuous	108	4.1	4.1	10.3	8.7	16.6	14.8
Signaling	49	11.3	8.4	8.6	6.3	24.4	20.4

^aDomain–domain interaction.