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. 2010 Oct 15;5(10):e13417. doi: 10.1371/journal.pone.0013417

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Giampà et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Kaplan-Meyer analysis of survival. R6/2 mice treated with TP-10 had a mean survival time that was significantly (p<0.0001) longer than that of R6/2 mice treated with vehicle. (B) Weight as a function of age in the wild type and R6/2 mice. The wild type mice gained weight throughout the course of the study, whereas the R6/2 mice progressively lost weight. There was no statistically significant effect of TP-10 treatment in either genotype. (C) The development of the hind-limb clasping phenotype in R6/2 mice treated with TP-10 or vehicle. Two way analysis of variance indicated a statistically significant effect of treatment (F(1,12) = 8,86, p<0.0116) and age (F(6,72) = 25,32, p<0.0000). Post hoc analysis indicated that the TP-10 treated mice showed significantly less clasping at weeks 10, 11, and 12 (*, p<0.01).