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. 2010 Oct 15;5(10):e13417. doi: 10.1371/journal.pone.0013417

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Giampà et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Quantification of the intensity of pCREB immunoreactivity associated with NeuN-labeled cortical neurons at age 13 weeks. The intensity of pCREB immunoreactivity associated with NeuN-positive cells were carried out (see Methods) on sections from wild type or R6/2 mice treated with vehicle or TP-10 from 4 to 13 weeks of age (n = 6/group). A two way ANOVA indicated an overall significant effect of genotype (F(1,1558) = 868.66; p<0.000) and treatment (F(1,1558) = 45.46; p<0.0000) and a genotype X treatment interaction (F(1,1558) = 45.46; p<0.0000). Post hoc analysis indicated that there was no statistically significant difference in pCREB level in wild type mice treated with TP-10 or vehicle. R6/2 mice treated with vehicle had a significantly reduced pCREB level compared to the vehicle treated wild type group. The pCREB level in R6/2 animals treated with TP-10 was not statistically different to that in the wild type groups, and was significantly greater than that of the vehicle treated R6/2 animals (p<0.000). (B) Intensity of BDNF immunoreactivity associated with NeuN-labeled cortical neurons. A two way ANOVA indicated an overall significant effect of groups (F(1,1148) = 540.66; p<0.000) and treatment (F(1,1148) = 52.13; p<0.0000) and a genotype X treatment interaction (F(1,1148) = 52.69; p<0.000). Post hoc analysis indicated that there was no statistically significant difference in BDNF level wild type mice treated with TP-10 or vehicle. R6/2 mice treated with vehicle had a significantly reduced BDNF level compared to the vehicle treated wild type group. The BDNF level of R6/2 animals treated with TP-10 was statistically different to that in the wild type groups, and was significantly greater than that of the vehicle treated R6/2 animals (p<0.000008).