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Plasma concentration of ADC-1004. (A) Plasma concentration over the entire experimental period. ADC-1004 was administered 20 minutes prior to reperfusion, marked by the dashed line. (B) Plasma concentration at sacrifice. The dashed line marks the desired level of ADC1004, a concentration that blocks 75% of the C5a receptors on the neutrophils. This level of blockage is considered to be therapeutic.
