Table 2.
Diseases, Molecular and Cellular Functions associated with genes up-regulated (A) and down-regulated (B) by Runx2
| A) ≥ 2 fold up-regulated, total 532 genes | p-value | genes |
|---|---|---|
| Diseases and disorders | ||
| Cancer | 2.5e-07 - 3.0e-03 | 124 |
| Genetic disorder | 5.4e-07 - 3.0e-03 | 229 |
| Inflammatory response | 3.3e-06 - 2.4e-03 | 65 |
| Molecular and cellular functions | ||
| Cellular movement | 9.7e-12 - 2.5e-03 | 84 |
| Cell death | 2.6e-10 - 3.2e-03 | 129 |
| Cellular growth, proliferation | 9.3e-08 - 3.2e-03 | 108 |
| B) ≥ 2 fold down-regulated, total 378 genes | ||
| Diseases and disorders | ||
| Cancer | 3.3e-29 - 4.1e-03 | 124 |
| Gastrointestinal disease | 3.3e-29 - 3.7e-03 | 72 |
| Genetic disorder | 3.3e-06 - 3.4e-03 | 174 |
| Molecular and cellular functions | ||
| Cell cycle | 7.1e-35 - 4.1e-03 | 102 |
| Cellular assembly, organization | 1.7e-18 - 3.4e-03 | 63 |
| DNA replication, recombination, repair | 1.7e-18 - 4.1e-03 | 101 |
IPA™ analysis indicating the association of Runx2-regulated genes to a particular category identifying the indicated disease or function. The ranges of p values indicate the statistical significance with which Runx2-regulated genes associate with the each category.