Table 3.

[³H] Ketanserin binding parameters in the hippocampus of control and experimental rats

Experimental Groups	Bmax (fmoles/mg protein)	Kd (nM)
Control	260.5 ± 0.35	0.68 ± 0.08
Diabetic	176.2 ± 0.19 b	0.77 ± 0.17 a
Diabetic + Insulin	218.1 ± 0.32 d	0.67 ± 0.09 c
Diabetic + Pyridoxine	180.6 ± 0.27 b	0.70 ± 0.06 c
Diabetic + Insulin+ Pyridoxine	244.0 ± 0.26 d	0.68 ± 0.11 c
Diabetic+A. marmelose	209.3 ± 0.22 d	0.68 ± 0.11 c
Diabetic+ A. marmelose +Pyridoxine	228.2 ± 0.29 d	0.67 ± 0.07 c

Values are mean ± S.E.M of 6-8 separate experiments. Each group consists of 6-8 rats.

^a p < 0.05, ^b p < 0.001 when compared to control;

^c p < 0.05, ^d p < 0.001 when compared to diabetic group.