Table 3.
Treatment effect in hemoglobin, ferritin and total iron concentrations of children
| Evaluation | IS | IFS | MMS | FW | FCF | p |
|---|---|---|---|---|---|---|
|
Hemoglobin (g/dL) |
||||||
| N | 40 | 42 | 36 | 48 | 51 | |
| Baseline | 10.45 (10.18, 10.72) | 10.72 (10.49, 10.95) | 10.73 (10.52, 10.94) | 10.55 (10.32, 10.78) | 10.51 (10.22, 10.80) | 0.487 |
| Final | 11.94 (11.60, 12.27)1 | 12.24 (11.90, 12.58)1 | 12.14 (11.80, 12.48)1 | 11.62 (11.28, 11.96) | 11.38 (11.07, 11.68)2 | 0.001 |
| Change | 1.49 (1.13, 1.84)†1 | 1.52 (1.13, 1.91)†1 | 1.41 (1.05, 1.76)†1 | 1.07 (0.77, 1.36)† | 0.86 (0.60, 1.13)†2 | 0.012 |
| Adjusted change * | 1.43 (1.05, 1.80) | 1.58 (1.26, 1.89)1 | 1.46 (1.08, 1.83)1 | 1.25 (0.89, 1.62) | 0.94 (0.65, 1.22)2 | 0.034 |
|
Ferritin (μg/dL) |
||||||
| N‡ | 29 | 32 | 23 | 38 | 46 | |
| Baseline | 30.04 (9.90, 50.18) | 72.18 (41.64, 102.71) | 22.83 (2.97, 42.69) | 60.93 (36.55, 85.31) | 57.95 (31.18, 84.72) | 0.073 |
| Final | 55.50 (26.79, 84.22) | 51.24 (26.83, 75.64) | 20.53 (4.12, 36.94) | 48.16 (21.33, 74.98) | 60.45 (32.26, 88.63) | 0.366 |
| Change | 25.47 (3.97, 46.96)†1 | -20.94 (-44.78, 2.89)2 | -2.30 (-10.61, 6.01) | -12.77 (-35.49, 9.95)2 | 2.49 (-17.90, 22.89) | 0.042 |
| Adjusted change * | 21.43 (-4.05, 46.91) | 0.94 (-19.50, 21.38) | 0.67 (-24.96, 26.30) | -4.06 (-26.80, 18.69) | 20.29 (2.97, 37.62) | 0.200 |
|
Total Iron (μg/dL) |
||||||
| N‡ | 26 | 30 | 21 | 33 | 46 | |
| Baseline | 1.05 (0.90, 1.20) | 1.01 (0.86, 1.16) | 1.04 (0.88, 1.19) | 1.17 (0.99, 1.34) | 1.04 (0.90, 1.17) | 0.822 |
| Final | 1.26 (1.08, 1.45) | 1.16 (1.03, 1.29) | 1.26 (1.02, 1.50) | 1.35 (1.17, 1.53) | 1.23 (1.09, 1.38) | 0.604 |
| Change | 0.21 (0.08, 0.35)† | 0.15 (0.04, 0.26)† | 0.23 (0.04, 0.42)† | 0.19 (0.06, 0.31)† | 0.20 (0.10, 0.29)† | 0.932 |
| Adjusted change * | 0.16 (0.00, 0.31) | 0.13 (0.01, 0.25) | 0.16 (0.00, 0.32) | 0.25 (0.11, 0.39) | 0.16 (0.05, 0.26) | 0.771 |
Treatment abbreviations: Iron supplement (IS), iron plus folic acid supplement (IFS), multiple micronutrients supplement (MMS), micronutrient fortified complementary food as porridge powder (FCF), or zinc, iron and ascorbic acid fortified water (FW).
Values are means (95% CI).
* Estimated changes adjusted for initial value, consumed iron in the treatment (according to formula and adherence to the treatment) and community.
† Change is significant within treatment at p < 0.05 in paired T-Test
‡ Excludes children with positive C-Reactive Protein from qualitative analysis
1,2 Different numbers indicate significant difference in the Least Significant Test at p < 0.05.