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Open Field Behavior. Effects of MSEW on open field behavior in 5 min time bins for Cohort 1 (A, B) and Cohort 2 (C, D) mice. In Cohort 1, MSEW and B6 animals moved faster (A; MSEW p < 0.05; B6 p < 0.0005) and spent more time in the center of the arena (B; MSEW p < 0.01; B6 p < 0.001) than control and D2 mice, respectively. In Cohort 2, MSEW animals moved faster during the first 5 min of testing (C; p < 0.005) and spent less time in the center of the arena (D; p < 0.05) than controls.
