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. 2010 Aug 4;35(12):2378–2391. doi: 10.1038/npp.2010.114

Figure 7.

Figure 7

Total CREB and pCREB levels are increased in the ventral striatum after 14 days of chronic, peripheral brain-derived neurotrophic factor (BDNF) administration. The inserts represent some of the western blots for total extracellular signal-regulated kinase (ERK), pERK, cAMP response element-binding protein (CREB), pCREB, and β-actin (loading control) in the hippocampus from the saline and 8.0 μg BDNF treatments. Densitometric values from all western blots were normalized to β-actin and then expressed as percentage control. (a) When analyzed with unpaired t-tests, total ERK1/2 (P=0.93), ERK1 (P=0.99), and ERK2 (P=0.89) levels were not significantly different between treatments. (b) No significant difference in levels of phosphorylated ERK1/2 (P=0.49), ERK1 (P=0.57), or ERK2 (P=0.34) in the ventral striatum were found between mice receiving saline or 8.0 μg BDNF (unpaired t-tests). Significant increases in total CREB (c) and pCREB (d) levels in the ventral striatum were revealed by unpaired t-tests (*P<0.05 when compared with control group). There were a total of seven subjects per treatment.