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. Author manuscript; available in PMC: 2011 Nov 4.
Published in final edited form as: Brain Res. 2010 Aug 21;1359:1–13. doi: 10.1016/j.brainres.2010.08.044

Figure 8. Drug Delivery to the Central Nervous System Via Choroid Plexus.

Figure 8

There are three modes of drug delivery to the CNS using the choroid plexus as a portal of entry. The first (1) is direct whereby molecules are targeted and directly translocated across the CP epithelial barrier to find their targets from within the CNS. A second (2) is illustrated by entering and trateing the CP epithelium so that its capacity the produce and composition of CSF is modified. These then find their targets in the CNS parenchyma. Finally the third strategy, in the example here using gene delivery, results in longer term changes of the choroid plexus, allows the epithelial cell to produce novel therapeutic factors itself and as such can confer the epithelium with an ability to change the production and composition of CSF. This latter process and the feasibility with luminal targeting (3) is demonstrated in the results presented here.