Table 2.
Effect of tryptophan-hydroxylase 2 (TPH2) haplotypes and alleles on aggression and affect lability scores in the European white subsample (including 38 healthy controls, 38 patients with BPD, and 47 patients with other PDs): Aggression is measured by self-report with a composite measure of the Buss Durkee Aggression Inventory and the Buss Perry Aggression Questionnaire (tBUSS). Affect lability was measured using the Affect Lability Scale (ALS). Individuals carrying one or more copies of the “risk” haplotype are grouped together.
| “risk” haplotype or allele (1 or 2 copies) | “non-risk” haplotype or allele (0 copies) | |||||
|---|---|---|---|---|---|---|
| SNP/haplotype | Measure | N | Mean (SD) | N | Mean (SD) | |
| Haplotype | tBUSS | 91 | 57.0 (17.8) | 17 | 47.6 (20.5) | t=−1.95, df= 106, p=0.05 |
| ALS | 90 | 1.1 (0.7) | 17 | 0.6 (0.6) | t=−2.77, df=105, p<0.01 | |
| 2171363 | tBUSS | 91 | 57.0 (17.9) | 17 | 47.6 (20.5) | t=−1.95, df= 106, p=0.05 |
| 6582078 | tBUSS | 91 | 57.0 (17.9) | 17 | 47.6 (20.5) | t=−1.95, df= 106, p=0.05 |
| 1352250 | tBUSS | 93 | 57.2 (18.0) | 15 | 45.5 (18.9) | t=−2.30, df=106, p<0.05 |
| Haplotype | Sui/parasuicidal behaviors | 45 | 0.89 (2.09) | 15 | 0.13 (0.35) | t=−2.33, df=50.64, p<0.05 |
| Haplotype | Depression (BDI) | 70 | 3.71 (7.12) | 14 | 9.94 (11.57) | t= −2.65, df=28.84, p<0.05 |