Table 2.
Chemical structures and IC50 values (μM) of all phenothiazines tested in the SAR study are reported. The phenothiazines active in our HT29 cell-based assay are listed according to their decreasing IC50 values starting with our parental compound 2-(trifluoromethyl)-phenothiazine. The phenothiazines unable to block ROS generation in our HT29 cell-based assay are also listed. Among these, several anti-psychotic drugs are also reported.
| Corp ID SID Common Name |
Micromolar IC50 HT29 Assay |
|
|---|---|---|
| SR-01000441858-2 26540425 JFD 03930 |
0.32 |  |
| SR-01000597201-3 SID 57287864 (ML171) |
0.129 (AID 2808) |  |
| SR-03000000698-1 57287906 |
0.177 (AID 2808) |  |
| SR-03000000756-1 57287964 |
0.24 (AID 2808) |  |
| SR-03000000755-1 57287963 |
0.24 (AID 2808) |  |
| SR-01000596948-2 7287863 |
0.25 |  |
| SR-03000000760-1 57287968 |
0.36 (AID 2808) |  |
| SR-01000721844-3 57287888 |
0.37 (AID 2808) |  |
| SR-03000000753-1 57287961 |
0.91 (AID 2808) |  |
| SR-01000477673-3 57287845 |
0.92 (AID 2808) |  |
| SR-01000025134-3 57287814 |
0.94 (AID 2808) |  |
| SR-03000000695-1 57287903 |
1.4 (AID2808) |  |
| SR-03000000707-1 57287915 |
5.3 (AID 2808) |  |
| SR-01000003048-5 57287813 Fluorophenazine |
Inactive (AID 2808) |  |
| SR-01000003020-6 57287812 |
Inactive (AID 2808) |  |
| SR-01000000228-4 57288080 promazine |
Inactive (AID 2808) |  |
| SR-01000000224-4 57288079 Triflupromazine |
Inactive (AID 2808) |  |
| SR-01000000137-4 57287811 |
Inactive (AID 2808) |  |
| SR-01000000012-5 57287810 chlorpromazine |
Inactive (AID 2808) |  |