Cannabinoid “tetrad” response in TIP39-KO and WT mice. Tests were performed in the order catalepsy (A), locomotion (B), analgesia on hot-plate (C) and body temperature (D) following administration of the cannabinoid agonist CP55,940 (0.3 mg/kg, i.p.). The only test in which CP55,940 treated TIP39-KO mice differed from TIP39-KO mice receiving vehicle was catalepsy (vehicle treated animals displayed no catalepsy; Bonferroni Posttest, ###P<0.001. WT mice treated with CP55,940 differed from WT receiving vehicle in all four tests ***P<0.001.