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Evaluation of stress-induced analgesia in PTH2R-KO mice. WT or PTH2R-KO mice were given rimonabant (5 mg/kg i.p.) or vehicle and after 30 min subjected to foot shock (or not) and evaluated in the hot-plate test. SIA was significantly greater in PTH2R-KO injected with vehicle than the WT (**Bonferroni Posttest, P<0.01), and this increase was completely blocked by rimonabant (P>0.05).
