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Comparison of the responses of TIP39-KO and WT mice in the tail-flick and hot-plate tests. The difference between TIP39-KO and WT mice was not significant in the tail-flick test (A), tail-immersion test at 55 °C (B) or in the hot-plate test performed at 42 °C (C) or 48 °C (D). The TIP39-KO had significantly greater response latency in the hot-plate test at 55 °C. *P<0.05 (E).
