Rimonabant prevents HYWH potentiation of stress-induced analgesia. Mice were treated with rimonabant (5 mg/kg i.p.) or vehicle and 30 min later infused with HYWH (500 pmol, icv) or vehicle, then exposed to foot shock, followed immediately by the hot-plate test. Mice receiving HYWH had greater analgesia without (*Bonferroni Posttest, P<0.05), but not following rimonabant administration (P>0.5 for Vehicle/Rimonabant versus HYWH/Rimonabant).