TABLE 1. GluA1 are normal on simple measures of physical health, neurological and sensory function.
Physical health, sensory reflexes, motor, neurological functions and simple behaviors in an empty cage were generally no different between genotypes. A greater proportion of KO exhibited missing whiskers and bald patches, forepaw clutching and defecation in an empty cage than WT. Unless a unit of measurement is given in parenthesis, data are the percentage of mice within each genotype showing a response (n=14/genotype). Redrawn from (Wiedholz et al., 2008).
| WT | KO | |
|---|---|---|
| Physical health | ||
| Missing whiskers | 20 | 47 |
| Bald patches | 13 | 27 |
| Piloerection | 0 | 0 |
| Exophthalmus | 0 | 0 |
| Palpebral closure | 0 | 0 |
| Straub tail | 0 | 0 |
| Kinked tail | 0 | 0 |
| Kyphosis | 0 | 0 |
| Lordosis | 0 | 0 |
| Body weight (g) | 21.5 | 22.9 |
| Core body temp (°C) | 36.5 | 36.3 |
| Sensory reflexes | ||
| Approach response | 100 | 100 |
| Touch response | 100 | 100 |
| Palpebral response | 100 | 80 |
| Tail pink response | 100 | 100 |
| Hotplate paw withdrawal latency (sec) | 11.49 ±0.86 | 9.67 ±0.94 |
| Tail flick latency (sec) | 2.02 ±0.07 | 1.85 ±0.15 |
| Motor, neurological | ||
| Splayed limbs | 0 | 0 |
| Forepaw clutch | 0 | 13 |
| Hindpaw clutch | 0 | 0 |
| Empty cage behaviors | ||
| Wild running | 0 | 0 |
| Freezing | 13 | 7 |
| Trembling | 0 | 0 |
| Sniffing | 100 | 100 |
| Licking | 0 | 0 |
| Rearing | 100 | 100 |
| Jumping | 0 | 0 |
| Seizure | 0 | 0 |
| Defecation | 20 | 60 |
| Urination | 7 | 13 |
| Head bobbing | 0 | 0 |
| Circling | 0 | 0 |
| Abnormal gait | 0 | 0 |
| Retropulsion | 0 | 7 |
| Prancing forelimbs | 0 | 0 |