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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Pancreas. 2010 Nov;39(8):1277–1283. doi: 10.1097/MPA.0b013e3181dd63e1

Figure 6. Vorinostat inhibits radiation-induced pro-survival signaling pathways.

Figure 6

(a) Vorinostat inhibits radiation-induced EGFR phosphorylation. MiaPaCa-2 cells were exposed to vorinostat (2 μM; 48 hr), irradiated (6 Gy), and harvested at indicated time points post-irradiation for immunoblot analysis. (b) Vorinostat decreases radiation-induced expression of phospho (active) c-jun. Cells were treated with vorinostat (2 μM; 48 h), irradiated (6 Gy), and harvested at indicated time points post-irradiation for immunobloting. (c) Effect of vorinostat on NF-κB activation. Cells were treated with indicated concentrations of vorinostat for 48 h, irradiated (6 Gy), and harvested 3 h post-irradiation. NF-κB activity in the nuclear fraction was analyzed by EMSA.