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. Author manuscript; available in PMC: 2011 Nov 4.
Published in final edited form as: Brain Res. 2010 Sep 21;1359:247–255. doi: 10.1016/j.brainres.2010.08.075

Fig. 2.

Fig. 2

Effects of fibrates on SOD mRNA levels in brain microvessels in nonischemic wild-type mice. (A) mRNA levels of SOD after fenofibrate treatments for 7 days in wild-type mice. Brains were collected at 1 hour or 3 days after the last fenofibrate administration. mRNA levels were determined by quantitative PCR normalized by GAPDH mRNA levels in each sample. For each gene, the mean value in vehicle group was considered as 1 and relative level was calculated and expressed for fenofibrate groups. For Veh, F30, F100, and F30D-3, please refer to Figure 1, Experiment I. Error bars, SD. ***p < 0.001 by ANOVA followed by Scheffe (n = 5—7 in each group). (B) Relationship between SOD mRNA and PPARα mRNA level on D-0. (C) mRNA levels of SOD after gemfibrozil treatments for 7 days in wild-type mice. Gemfibrozil (30 or 120 mg/kg) or vehicle (Veh) was given for 7 days. Brains were collected at 1 hour after the last gemfibrozil administration. **p < 0.01 and ***p < 0.001 by ANOVA followed by Scheffe (n = 7 in each group).