Effects of fenofibrate on total (A), cortical (B), and subcortical (C) infarct size in C57BL/6 wild-type mice subjected to 60 minutes of MCAO and 24 hours of reperfusion. NoTx, non-fenofibrate treated group (n = 13). D-0, the group was treated with fenofibrate (30 mg/kg) for 7 days and was subjected to ischemia at 1 hour after the last fenofibrate administration (n = 10). D-3, the group was treated with fenofibrate (30 mg/kg) for 7 days and was subjected to ischemia 3 days after the last fenofibrate administration (n = 11). Horizontal bars, mean. Statistical analysis was done by one way ANOVA followed by Scheffe post hoc test.