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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Biol Psychiatry. 2010 Aug 17;68(9):801–810. doi: 10.1016/j.biopsych.2010.06.019

Figure 5. Effect of Cacna1c HET knockout on depression-like behavior in the learned helplessness model.

Figure 5

Mice were tested one and seven days after induction of learned helplessness with 0.3 mA inescapable shocks. In trials P1–P5, shock start and gate opening was simultaneous. In trials 1–25, a delay of three seconds was imposed between shock start and gate opening. In male mice on days 1 (a) and 7 (c), there was no significant effect of genotype in trials P1–P5, and in trials 1–25. In female mice on days 1 (b) and 7 (d), there were no significant differences in performance in trials P1–P5, but there was a significant effect of genotype in trials 1–25 (P<0.05). Data are expressed as mean ± SEM.