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. Author manuscript; available in PMC: 2011 Oct 15.
Published in final edited form as: ACS Chem Biol. 2010 Oct 15;5(10):919–923. doi: 10.1021/cb1001747

Figure 2.

Figure 2

Evaluation of structures from the Protein Data Bank to identify and assess helical interfaces in protein–protein (HIPP) interactions. The helical interfaces were segregated based on binding interfaces and computational alanine scanning mutagenesis analysis. *ΔΔGavg ≥ 2 kcal/mol; ** ΔΔGavg = 1–2 kcal/mol.