Figure 10.

Nicotine exposure during early postnatal development is sufficient to induce hypersensitive passive avoidance performance. C57BL/6J mice were cross-fostered between nicotine- and saccharin-exposed dams at birth and tested for passive avoidance as adults. Mice were exposed to nicotine throughout gestation and postnatal development to 21 days of age (NN), between birth and 21 days of age (SN), only during gestation (NS) or were exposed only to saccharin (SS). A significant main effect of postnatal nicotine exposure was detected on the test day (F(1, 14)=7.511, p=0.016; n=8 per group). No main effect of prenatal exposure and no interaction between pre- and postnatal exposure was detected. ^★p<0.05.