Table 1.

SardiNIA and BLSA meta-analysis of association results for trait depression.

					Imputation quality (r2)		Effect-allele frequency		Effect size		p-value
SNP	Gene	chr	position	Effect-allele	SardiNIA	BLSA	SardiNIA	BLSA	SardiNIA	BLSA	SardiNIA	BLSA	Meta-analysis
rs12912233	RORA	15	59.05	T/C	0.54	0.96	.46	.46	0.15	0.09	1.8 ×10−6	6.1 ×10−2	6.3 ×10−7
rs8070473	SLFN12L	17	30.87	T/G	0.81	0.99	.32	.32	−0.16	−0.07	1.1 ×10−6	2.3 ×10−1	1.5 ×10−6
rs349475	CDH18*	5	19.48	T/C	0.66	0.86	.29	.29	0.18	0.02	2.4 ×10−7	7.3 ×10−1	2.4 ×10−6
rs12420464	EIF3F	11	7.97	T/G	0.37	GN	.04	.04	−0.38	−0.08	1.3 ×10−6	3.8 ×10−1	3.3 ×10−6
rs8068353	SLFN12L	17	30.86	C/G	0.78	0.93	.32	.32	−0.15	−0.08	4.4 ×10−6	1.6 ×10−1	3.4 ×10−6
rs1927745	FAM155A*	13	106.58	A/G	0.66	GN	.24	.24	−0.16	−0.06	3.5 ×10−6	2.4 ×10−1	4.7 ×10−6
rs10514585	CDH13	16	81.84	A/G	GN	0.99	.31	.31	0.15	0.06	3.1 ×10−6	2.8 ×10−1	4.9 ×10−6
rs11009175	ITGB1*	10	33.33	A/G	0.86	0.96	.17	.17	0.16	0.16	4.2 ×10−5	2.3 ×10−2	5.4 ×10−6
rs17864092	GRM8	7	126.23	T/C	0.65	GN	.90	.90	−0.17	−0.25	1.9 ×10−4	2.2 ×10−3	5.5 ×10−6
rs9634463	FAM155A*	13	106.57	T/C	0.89	0.90	.24	.24	−0.16	−0.05	2.5 ×10−6	3.7 ×10−1	5.7 ×10−6
rs7329003	FAM155A*	13	106.57	A/G	GN	0.90	.75	.75	−0.16	−0.05	2.5 ×10−6	3.7 ×10−1	5.8 ×10−6
rs713548	FAM155A*	13	106.57	T/G	0.91	0.90	.25	.25	−0.16	−0.05	2.6 ×10−6	3.7 ×10−1	5.9 ×10−6
rs4775340	RORA	15	59.06	A/G	0.55	GN	.43	.43	0.14	0.09	2.1 ×10−5	6.5 ×10−2	6.3 ×10−6
rs1449984	-	2	23.33	A/G	0.96	GN	.72	.72	−0.15	−0.06	6.7 ×10−6	2.0 ×10−1	6.6 ×10−6
rs9301191	FAM155A*	13	106.57	T/C	0.85	0.90	.79	.79	−0.17	−0.05	2.9 ×10−6	3.9 ×10−1	7.1 ×10−6
rs8028646	RORA	15	59	A/T	GN	0.99	.25	.25	−0.14	−0.15	1.6 ×10−4	4.6 ×10−3	7.2 ×10−6
rs1924397	FAM155A*	13	105.41	A/C	0.54	0.80	.96	.96	0.32	0.15	2.0 ×10−5	8.3 ×10−2	7.6 ×10−6
rs10744304	-	12	126.34	A/G	0.68	GN	.63	.63	−0.15	−0.05	5.0 ×10−6	3.2 ×10−1	8.7 ×10−6
rs2017305	DDX21*	10	70.38	A/G	1.00	0.97	.92	.92	−0.22	−0.21	6.9 ×10−5	2.3 ×10−2	9.0 ×10−6
rs3740596	DDX50	10	70.34	A/G	1.00	0.97	.92	.92	−0.22	−0.20	6.8 ×10−5	2.6 ×10−2	9.5 ×10−6
rs12638201	CCR9	3	45.91	A/G	0.82	GN	.14	.14	0.17	0.19	4.9 ×10−5	4.9 ×10−2	1.1 ×10−5
rs4796093	SLFN12L	17	30.87	A/G	0.89	GN	.64	.64	−0.14	−0.06	9.3 ×10−6	2.6 ×10−1	1.2 ×10−5
rs4885589	-	13	78.45	T/C	0.86	0.96	.60	.60	0.10	0.18	1.1 ×10−3	2.4 ×10−4	1.3 ×10−5
rs1539163	DDX21	10	70.41	T/C	1.00	0.96	.08	.08	−0.21	−0.21	1.1 ×10−4	2.4 ×10−2	1.4 ×10−5
rs8023563	RORA	15	59	A/T	GN	0.98	.76	.76	−0.13	−0.15	2.9 ×10−4	5.4 ×10−3	1.5 ×10−5

^*Nearest gene. GN = Genotyped. The first allele in the Effect-allele column is the reference allele for allele frequency and effect size direction.