. 2010 Sep 22;140(11):2020–2027. doi: 10.3945/jn.110.129197

TABLE 2.

Total cell counts and thymocyte subpopulations in GCN2^+/+ and GCN2^{#x2212/#x2212} mice administered ASNase at 3 IU/g body weight or equivolume PBS for 6 d¹

	GCN2^+/+		GCN2^−/−		P-value
	PBS	ASNase	PBS	ASNase	Genotype	ASNase	G × A
	cells x 10⁶
Total	78.28 ± 9.49^a	41.23 ± 8.29*^b	69.68 ± 11.60 ^#a	2.36 ± 0.66^#*^c	<0.001	<0.001	<0.001
CD4-CD8-	1.53 ± 0.20^a	1.50 ± 0.17*^a	1.32 ± 0.20^#a	0.25 ± 0.04^#*^b	<0.001	<0.001	<0.001
CD4+CD8+	66.31 ± 8.72^a	33.18 ± 7.46*^b	57.66 ± 7.74^#a	0.10 ± 0.05^#*^c	<0.001	<0.001	<0.001
CD4+CD8-	8.08 ± 0.75^a	5.05 ± 0.65*^b	8.21 ± 1.86^#a	1.49 ± 0.45^#*^c	<0.001	0.003	0.007
CD4-CD8+	2.47 ± 0.51^a	1.50 ± 0.14*^b	2.49 ± 0.65^#a	0.48 ± 0.14^#*^c	<0.001	0.005	0.006

Data are means ± SEM, = 6. ^#Different from corresponding GCN2^+/+, P < 0.05; *different from corresponding PBS, P < 0.05. When the genotype × ASNase interaction was significant, labeled means without a common letter differ, P < 0.05.