TABLE 4.

Total cell counts and B lymphocyte subpopulations in the bone marrow of GCN2^+/+ and GCN2^{#x2212/#x2212} mice administered ASNase at 3 IU/g body weight or equivolume PBS for 6 d¹

	GCN2+/+		GCN2−/−		P-value
	PBS	ASNase	PBS	ASNase	Genotype	ASNase	G × A
	cells x 106
Total	18.19 ± 1.74a	16.35 ± 1.33*a	15.85 ± 0.73#a	5.08 ± 0.38*#b	<0.001	<0.001	0.001
B220- sIgM-	8.19 ± 0.90a	10.01 ± 1.00a	7.79 ± 0.74a	3.98 ± 0.29b	ns2	ns	0.002
B220+ sIgM-	5.26 ± 0.48a	3.14 ± 0.45*b	4.16 ± 0.60#a	0.14 ± 0.02*#c	<0.001	<0.001	< 0.001
B220+ sIgM+	4.62 ± 0.74a	3.06 ± 0.60*b	3.82 ± 0.15#a	0.92 ± 0.10*#c	<0.001	<0.001	0.003

¹Data are means ± SEM, = 6. ^#Different from corresponding GCN2^+/+, P < 0.05; *different from corresponding PBS, P < 0.05. When the genotype × ASNase interaction was significant, labeled means without a common letter differ, P < 0.05; ²ns, Not significant, P > 0.05.