Table 2.
Population characteristics over time.
| Factors | All n = 121 (3/2003–11/06) | By date of transplant |
||
|---|---|---|---|---|
| First Half n = 60 (3/03–3/05) | Second Half n = 61 (3/05–11/06) | p (1st vs. 2nd half) | ||
| Donor features | ||||
| Age (years) | 36.6 = 11.0 | 35.7 ± 10.9 | 37.4 ± 11.2 | .383 |
| Female %/Male % | 55/45 | 53/47 | 57/43 | .655 |
| Related donor | 94 (78%) | 49 (82%) | 45 (74%) | .297 |
| Right lobe volume (by CT) (cc) | 1085 ± 236 | 1057 ±239 | 1112 ±232 | .201 |
| % Macrovesicular steatosis | 5.46 ± 7.18 | 4.90 ± 6.95 | 6.02 ± 7.42 | .395 |
| Positive crossmatch | 14 (12%) | 4 (7%) | 10 (16%) | .094 |
| Recipient features | ||||
| Age | 51.0 ± 13.3 | 50.0 ± 14.3 | 53.0 ± 12.2 | .219 |
| Female %/Male % | 58/42 | 58/42 | 57/43 | .915 |
| MELD at transplant | 12.7 ± 4.7 | 13.7 ±4.8 | 11.7 ±4.4 | .022 |
| No antibody pretreatment | 58 (48%) | 14 (23%) | 44 (72%) | .000 |
| Donor cell infusion | 10 (8%) | - | 10 (16%) | .001 |
| Graft/recipient body weight | 1.49 ± 0.51 | 1.46 ± 0.46 | 1.53 ± 0.57 | .426 |
| Surgery time (minutes) | 520 ± 125 | 538 ± 123 | 502 ± 126 | .117 |
| Duct to duct biliary reconstruction | 85 (70%) | 39 (65%) | 46 (75%) | .210 |
| More than 1 donor bile duct | 42 (35%) | 21 (35%) | 21 (34%) | .947 |
| Normal arterial reconstruction | 97 (80%) | 44 (73%) | 53 (87%) | .062 |
| Use of portal vein graft | 8 (7%) | 2 (3%) | 6 (10%) | .150 |
| Diagnostic categories | .947 | |||
| Cancer present | 15 (12%) | 8 (13%) | 7 (12%) | |
| Cholestalic | 33 (27%) | 15 (25%) | 18 (30%) | |
| Metabolic and other | 15 (12%) | 8 (13%) | 7 (12%) | |
| NASH | 10 (8%) | 4 (7%) | 6 (10%) | |
| Viral cirrhotic | 21 (17%) | 10 (17%) | 11 (18%) | |
| Non-viral cirrhotic | 27 (22%) | 15 (25%) | 12 (20%) | |
| Serious complications | ||||
| Biliary | 51 (42%) | 23 (38%) | 28 (46%) | .080 |
| Vascular | 18 (15%) | 6 (10%) | 12 (20%) | .033 |
| Other | 11 (9%) | 5 (8%) | 6 (10%) | .281 |
| No serious complications | 41 (34%) | 26 (43%) | 15 (25%) | a |
| One year patient/graft survival (%) | 91/84 | 95/88 | 87/80 | |
a
The statistical significance of biliary, vascular, and other complications was tested with a chi-square method using the no serious complications group as a comparator. For all other factors, t-tests were used for continuous variables and chi-square tests for categorical variables. Statistically significant P values are in italics.