Table 3.
Serial renal function and tacrolimus levels prior to, on the day of, and 7 days following protocol biopsies performed 1 week after transplantation
| D−7 | D−3 | D−1 | D0 | D + 7 | ||
|---|---|---|---|---|---|---|
| Borderline or acute tubulitis (n=13) | Serum creatinine (mg/dL) | 6.0 ± 3.1 | 2.9 ± 2.5 | 2.4 ± 2.0 | 2.1 ± 1.7 | 1.6 ± 0.7 |
| Tacrolimus levels (ng/mL) | 20.0 ± 4.8 | 22.0 ± 6.1 | 19.1 ± 3.6 | 16.6 ± 4.9* | 20.2 ± 4.2 | |
| No tubulitis (n=15) | Serum creatinine (mg/dL) | 8.8 ± 4.3 | 4.1 ± 3.4 | 2.7 ± 1.8 | 2.3 ± 1.4 | 2.1 ± 1.5 |
| Tacrolimus levels (ng/mL) | 28.4 ± 12.0 | 24.7 ± 14.7 | 22.9 ± 6.4 | 25.1 ± 7.6 | 20.8 ± 6.0 |
p < 0.002.