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Dose-escalation scheme, dose-limiting toxicity, and response
| Dose level of docetaxel | Patients | Cycles | DLT | Type | Response |
|---|---|---|---|---|---|
| 30 mg/m2 | 6 | 24 | 2 | 2 Febrile neutropenia | 2 CR, 3 PR,1 PD |
| 35 mg/m2 | 6 | 27 | 2 | 1 Febrile neutropenia | 3 CR, 3 PR |
| 1 Anemia | |||||
| 40 mg/m2 | 6 | 19 | 3 | 2 Febrile neutropenia | 1 CR, 4 PR,1 SD |
| 1 Neutropenia | |||||
| Total | 18 | 70 | 7 | Response rate: 88.9% |
DLT dose-limiting toxicity, CR complete response, PR partial response, SD stable disease, PD progressive disease
