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The domain structure of the two DNA damage-dependent human PARPs, PARP-1 and PARP-2, showing the DNA-binding, the automodification and catalytic domains (domains A–F). The PARP signature sequence (in dark blue within the F catalytic domain) is the most conserved between the PARPs. Zn I and Zn II: Zinc-finger motifs. Zn III: Zinc ribbon domain. NLS nuclear localization signal; BRCT BRCA1 carboxy terminus; NoLS nucleolar localization signal
