Figure 4. Attention task 4 (Variable pre-cue delay: 0, 2, 4 s; variable cue duration: 0.8, 1.0, or 1.4 s).

(A) Mean (± SE) percentage of correct responses (averaged across all other conditions): The unsupplemented Ts65Dn mice performed significantly worse than the two groups of 2N mice. The Ts65Dn mice supplemented with choline early in life performed significantly better than the unsupplemented Ts65Dn mice and did not differ from the 2N mice. (B) Mean (± SE) percentage of correct responses as a function of the pre-cue delay: The unsupplemented Ts65Dn mice performed significantly worse than the unsupplemented 2N controls at all delays. In contrast, the choline-supplemented Ts65Dn mice did not differ significantly from either group of 2N mice for trials with either a 0s or 4s pre-cue delay, while still not differing from the supplemented 2N mice. In addition, the supplemented trisomic mice performed significantly better than their unsupplemented counterparts for trials with a 0 s or 4s pre-cue delay. (C) Mean (± SE) percentage of trials with a long Alcove Latency (> 5s), as a function of the outcome of the previous trial (correct or incorrect): No group differences were seen for trials that followed a correct response. However, for trials that followed an error, the incidence of trials with a long AL was significantly greater for the unsupplemented trisomic mice than for the two groups of 2N mice and the supplemented trisomic mice.

*, p < 0.05, compared with the unsupplemented Ts65Dn mice