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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: Behav Neurosci. 2010 Jun;124(3):346–361. doi: 10.1037/a0019590

Figure 6. Videotape results.

Figure 6

(A) Difference between the average number of jumps/trial following an error and following a correct response (in Attention Task 3). Each dot represents one mouse. The unsupplemented trisomic mice exhibited pronounced jumping specifically after an error, contrary to the 2N mice who jumped relatively little after either an error or a correct response. The perinatal choline supplementation was not effective in normalizing this heightened reactivity to committing an error (p = 0.60; unsupplemented vs. supplemented trisomic). The perinatal choline supplementation did not affect this measure for the 2N mice (p =0 .50). (B) Activity level (square crossings/trial) in Attention Task 3, as a function of the outcome of the previous trial: The four groups did not differ significantly in square crossings per trial following a correct response (treatment group, p = 0.72). In contrast, the increase in activity level following an error (relative to after a correct response) was significantly greater for the trisomic mice than for the 2N controls (p = 0.003); this effect was not modified by perinatal choline supplementation (p = 0.21; unsupplemented vs supplemented trisomic mice). Perinatal choline supplementation did not affect activity level of the 2N mice for any condition. (C) Activity level (square crossings/trial) on RO Task, as a function of previous trial outcome: The increase in activity level seen following an error or a RO, relative to a correct response was significantly greater for the unsupplemented trisomic mice than for the 2N controls (respectively, p = 0.02 and 0.007). In contrast, the trisomic mice supplemented with choline early in life did not differ from the 2N controls for the difference score relating post-error activity to that seen after a correct response (p < 0.36), or post-RO activity relative to after a correct response (p > 0.33). Correspondingly, the post-error increase in activity (relative to after a correct response) was significantly greater for the unsupplemented trisomic mice than for their supplemented counterparts (p < 0.03).