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Reconstitution of Wild-Type Mice with Ndfip1−/− Marrow Leads to Inflammatory Disease
C57BL6 mice were lethally irradiated and then reconstituted with Ndfip1−/− bone marrow cells. The resulting mice developed skin lesions between 6 and 8 weeks of age.
(A) The skin lesions showed an infiltration of inflammatory cells.
(B and C) Histological findings in spleen (B) and liver (C) were similar to those seen in Ndfip1−/− mice. a, inflammation; b, extramedullary hematopoiesis.
