Table 3.

Statistical analysis of fentanyl plasma pharmacokinetic parameters in female and male subjects after administration of a single 800 µg fentanyl buccal soluble film

	Geometric LSM*
Parameter	Female	Male	Ratio of LSM for Female/Male, %
ln Cmax	1.265	1.337	94.46
ln AUClast	10.693	11.389	93.89
ln AUCinf	12.738	12.483	102.05

^*Values are the least squares means (LSMs). LSMs are the average of means associated with a treatment.

AUC_inf = area under the drug concentration time curve from time zero extrapolated to infinity; AUC_last = area under the drug concentration time curve from time zero to the time of the last measurable concentration; C_max = maximum observed plasma drug concentration.