Table 4.

Exposure to fentanyl after administration of a single 800 µg fentanyl buccal soluble film or four 200 µg fentanyl buccal soluble films

	Geometric LSM*
Parameter	Four × 200 µg Films	Single 800 µg Film	Ratio of LSM for 4 × 200 µg/800 µg, %; 90% CI	anova CV%
ln Cmax	1.269	1.301	97.50; 90.50–105.04	9.83
ln AUClast	11.283	11.036	102.24; 96.61–108.21	7.48
ln AUCinf	12.625	12.610	100.12; 94.00–106.64	8.32

^*Values are the least squares means (LSM).

anova = analysis of variance; AUC_inf = area under the drug concentration time curve from time zero extrapolated to infinity; AUC_last = area under the drug concentration time curve from time zero to the time of the last measurable concentration; CI = confidence interval; C_max = maximum observed plasma drug concentration; CV = coefficient of variation.

anova CV% is the square root of the residual variance times 100.