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. Author manuscript; available in PMC: 2010 Oct 16.
Published in final edited form as: Neuron. 2008 Oct 23;60(2):353–366. doi: 10.1016/j.neuron.2008.08.027

Figure 2. Transient Expression of CaMKII-F89G Activity Selectively during the Recall Stage Impaired Retrievals of One-Hour Memories.

Figure 2

Memory retrieval deficits of Tg mice in one-hour novel object recognition recall test (A), one-hour contextual fear memory recall test (B), and one-hour cued fear memory recall test (C) (12 animals in each group per test; p < 0.01). Since a single i.p. injection can provide consistent and complete in vivo inhibition of αCaMKII-F89G activity between 10 and 40 min postinjection, we designed a two-injection protocol so that αCaMKII-F89G activity would be expressed by the time of recall. The black bar above the timeline on the top of Figures A–C represents the period in which CaMKII-F89G in Tg mice was expressed. The first NM-PP1 (16.6 ng/g) was given 15 min before training, while the second NM-PP1 was introduced by i.p. injection 10 min after training. All values are mean ± SEM; **p < 0.01.