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. Author manuscript; available in PMC: 2011 Oct 15.
Published in final edited form as: Cell. 2010 Oct 15;143(2):299–312. doi: 10.1016/j.cell.2010.09.013

Figure 4. Insulin/IGF-1 signaling regulates reproductive aging non-autonomously in intestine and muscle.

Figure 4

(A) daf-16 germline silent worms (daf-16(mu86);daf-2(e1370);muIs105 [Pdaf-16::gfp::daf-16 +rol-6(su1006)], Figure S4) with only somatic daf-16 activity have a reproductive span similar to daf-2 mutants (statistics in Table S1).

(B-D) daf-16 activity in intestine (B and D) and muscle (C and D) significantly restores reproductive span extension, while neuronal daf-16 activity (C and D) does not.

(E and F) Oocyte (E) and distal germline (F) morphology scores of day 8 mated daf-16;daf-2, daf-2, endogenous-promoter-driven and tissue-specific promoter-driven daf-16 transgenic animals. *p < 0.05, ** < 0.01, *** < 0.001 for daf-16;daf-2 versus other genotypes.