Table 1.
Tertiary structures of allergens
| Allergen | Species of origin | Function/structure | X-ray crystal structure | NMR structure | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Inhaled – indoors | |||||||||||
| Bla g 2 | Blattella germanica | inactive aspartic protease | 1YG9* | 2NR6*,1 | |||||||
| Bla g 4 | Blattella germanica | lipocalin | 3EBK | ||||||||
| Blo t 5 | Blomia tropicalis | unknown | 2JMH | ||||||||
| Bos d 2 | Bos domesticus | lipocalin | 1BJ7 | ||||||||
| Der f 1 | Dermatophagoides farinae | cysteine protease | 3D6S | ||||||||
| Der f 2 | Dermatophagoides farinae | lipid-binding protein | 1XWV | 2F08 | 1AHK | 1AHM | 1WRF | ||||
| Der f 13 | Dermatophagoides farinae | fatty acid-binding protein | 2A0A | ||||||||
| Der p 1 | Dermatophagoides pteronyssinus | cysteine protease | 1XKG | 2AS8* | 3F5V | ||||||
| Der p 2 | Dermatophagoides pteronyssinus | lipid-binding protein | 1KTJ* | 1A9V* | |||||||
| Fel d 1 | Felis domesticus | uteroglobin | 1PUO* | 1ZKR* | 2EJN* | ||||||
| Mus m 1 | Mus musculus | lipocalin | 1MUP | ||||||||
| Per a 4 | Periplaneta americana | lipocalin | 3EBW | ||||||||
| Rat n 1 | Rattus norvegicus | lipocalin | 2A2G | 2A2U | |||||||
| Inhaled – outdoors | |||||||||||
| Amb t 5 | Ambrosia trifida | unknown | 1BBG | 2BBG | 3BBG | ||||||
| Ara t 8 | Arabidopsis thaliana | profilin | 1A0K | 3NUL | |||||||
| Bet v 1 | Betula verrucosa | pathogenesis-related protein | 1BV1 | 1QMR* | 1FM4 | 1LLT* | 1FSK1 | 1BTV | 1B6F | ||
| Bet v 2 | Betula verrucosa | profilin | 1CQA | ||||||||
| Bet v 4 | Betula verrucosa | Ca-binding protein | 1H4B | ||||||||
| Che a 3 | Chenopodium album | polcalcin | 2OPO | ||||||||
| Chi t 1 | Chironomus thummi thummi | hemoglobin | 1ECO | ||||||||
| Equ c 1 | Equus caballus | lipocalin | 1EW3 | ||||||||
| Hev b 6 | Hevea brasiliensis | hevein precursor | 1Q9B | 1WKX | 1T0W | 1HEV | |||||
| Hev b 8 | Hevea brasiliensis | latex profilin | 1G5U | ||||||||
| Jun a 1 | Juniperus ashei | pectate lyase | 1PXZ | ||||||||
| Ole e 6 | Olea europaea | unknown | 1SS3 | ||||||||
| Ole e 9 | Olea europaea | β-1,3-glucanase (C-terminus) | 2JON | ||||||||
| Phl p 1 | Phleum pratense | expansin | 1N10 | ||||||||
| Phl p 2 | Phleum pratense | grass group II/III | 1WHO | 1WHP | 2VXQ1 | 1BMW | |||||
| Phl p 3 | Phleum pratense | grass group II/III | 2JNZ | ||||||||
| Phl p 5 | Phleum pratense | unknown | 1L3P | ||||||||
| Phl p 6 | Phleum pratense | unknown | 1NLX | ||||||||
| Phl p 7 | Phleum pratense | Ca-binding protein | 1K9U | ||||||||
| Zea m 1 | Zea mays | β-expansin | 2HCZ | ||||||||
| Ingested – food | |||||||||||
| Api g 1 | Apium graveolens | pathogenesis-related protein | 2BK0 | ||||||||
| Ara h 3 | Arachis hypogaea | cupin (11S globulin, glycinin) | 3C3V | ||||||||
| Ara h 6 | Arachis hypogaea | conglutin (2S albumin) | 1W2Q | ||||||||
| Bos d 4 | Bos domesticus | α-lactalbumin | 1F6R | 1F6S | 1HFZ | 2G4N | |||||
| Bos d 5 | Bos domesticus | β-lactoglobulin | 1GX8 | 1GX9 | 2AKQ | 1BSO | 1UZ2* | 2R561 | |||
| Gal d 2 | Gallus domesticus | ovalbumin | 1JTI* | 1OVA | 1UHG* | ||||||
| Gal d 3 | Gallus domesticus | ovotransferrin | 1RYX | 2D3I | 1OVT | 1AIV | 1TFA | 1IEJ | |||
| Gal d 4 | Gallus domesticus | lysozyme2 | 1LYZ | 1H6M* | 1YQV1 | 1FDL1 | 1MLC1 | 3HFM1 | 1GXV | 1GXX | |
| Mus a x | Musa acuminata | banana glucanase | 2CYG | ||||||||
| Pru av 2 | Prunus avium | thaumatin-like protein | 2AHN | ||||||||
| Pru p 3 | Prunus persica | nonspecific lipid transfer protein | 2ALG | 2B5S | |||||||
| Ric c 3 | Ricinus communis | 2S albumin storage protein | 1PSY | ||||||||
| Injected | |||||||||||
| Api m 1 | Apis mellifera | phospholipase A2 | 1POC | ||||||||
| Api m 2 | Apis mellifera | hyaluronidase | 1FCQ | 1FCU | 1FCV | 2J881 | |||||
| Api m 4 | Apis mellifera | mellitin | 2MLT | 1BH1* | |||||||
| Sol i 3 | Solenopsis invicta | unknown | 2VZN | ||||||||
| Ves v 2 | Vespula vulgaris | hyaluronidase | 2ATM | ||||||||
| Ves v 5 | Vespula vulgaris | antigen 5 | 1QNX | ||||||||
| Through skin | |||||||||||
| Mala s 1 | Malassezia sympodialis | β-propeller fold | 2P9W | ||||||||
| Mala s 6 | Malassezia sympodialis | cyclophilin | 2CFE | ||||||||
| Mala s 13 | Malassezia sympodialis | thioredoxin | 2J23 | ||||||||
*
Modified or mutated molecule.
1
Allergen in complex with an antibody fragment.
2
Structures selected from multiple Protein Data Bank entries.