Table 1.
Clinical and laboratory characteristics of the study subjects
| Controls | CD | GS | |
|---|---|---|---|
| Samples, n | 7 | 13 | 11 |
| Age at diagnosis, years | 29.1 ± 5.1 | 35.2 ± 3.3 | 28.9 ± 4.4 |
| Sex (F/M) | 2/5 | 11/2 | 7/4 |
| Intestinal symptoms | dyspepsia | chronic diarrhea | diarrhea |
| abdominal pain | abdominal pain | ||
| weight fluctuation | weight fluctuation | ||
| weakness | gas | ||
| smelly, fatty stool | |||
| Extraintestinal symptoms | none | bone or joint pain | bone or joint pain |
| osteoporosis | osteoporosis | ||
| behavioral changes | leg numbness | ||
| tingling leg numbness | muscle cramps | ||
| muscle cramps | unexplained anemia | ||
| missed menstrual periods | glossitis | ||
| infertility | thyroiditis | ||
| recurrent miscarriage | |||
| delayed growth | |||
| tooth discoloration | |||
| unexplained anemia | |||
| EMA-IgA | all negative | 12 positive (92%) | all negative |
| tTG-IgA | all negative | 11 positive (85%) | all negative |
| AGA-IgA/IgG | all negative | 7 positive (54%) | 5 positive (46%) |
| MHC profile | 2 DQ2 and/or DQ8 (29%) | 12 DQ2 and/or DQ8 (92%) | 4 DQ2 and/or DQ8 (36%) |
| Wheat IgE | not tested | all negative | all negative |
| LA/MA test | normal (<0.030) | altered (>0.030) | normal (<0.030) |
EMA = Anti-endomysium antibodies; AGA = anti-gliadin antibodies; MHC = major histocompatibility complex; LA/MA = lactulose/mannitol.