. 2010 Mar 16;2(3):204–215. doi: 10.1159/000296507

Table 1.

Mononuclear phagocyte subpopulations in human disease

Disease	Prevalent subpopulation(s)	References¹
Solid tumors	M2 macrophages (TAMs) [any phenotype other than classic M1 macrophage]	Mantovani, 2002, 2004
	CD14^dim/CD16⁺/Tie2⁺/CD45⁺/CD11b⁺/L-selectin⁻/CCR2⁻	De Palma, 2005; Venneri, 2007; Murdoch, 2007

Sepsis	PBMs: CD14^bright/CD16⁺/HLA-DR⁺/CD86⁺/CD11b⁺/CD33⁺; low phagocytic ability	Schinkel, 1999; Skrzeezyñska, 2002; Fingerle, 1993

COPD	AMs: CD14^bright/CD16⁺/CD11c^bright/CD86⁺/CD11a⁺	Löfdahl, 2006; Zhou, 2009

Atherosclerosis	PBMs: CD14^bright/CD16⁺/CDt62-L^bright	Boudjeltia, 2008
	PBMs: CD14^bright/CD16⁻	Mosig, 2009
	PBMs: CD14^dim/CD16⁺/ScR⁺/DR^bright	Draude, 1999; Belge, 2002
	PBMs: CD14^dim or ^bright/CD16⁺ (obesity)	Rogacev, 2009

Cystic fibrosis	PBMs: CD14^dim or ^bright/CD16⁻/CCR2⁺	Rao, 2009

Sarcoidosis	PBMs: CD14^dim/CD16⁺/CD69⁺/VLA-1⁺	Heron, 2008; Okamoto, 2003
	PBMs: CD14^bright/CD16⁻/P₂X₇^bright	Okamoto, 2003

IPF	PBMs and AMs: increased CD14^dim/CD16⁺/CD11b⁺	Hogsteden, 1992
	PBMs and AMs: CD13⁺/CD14^dimCD33⁺/U26⁺/Max3⁺	Hogsteden, 1993
	AMs higher than PBMs: RFD9⁺/CD68⁺
	AMs: increased DDR1b⁺ on CD14^dim cells	Matsuyama, 2005

CILD	AMs: CD14^dim/CD16⁺/CD11b⁺/HLA-DR⁺	Krombach, 1996

Asthma	PBMs: increased CD14^dim/CD16⁺	Rivier, 1995; Tomita, 2002
	AMs: increased CD16⁺/CD18⁺/CDw32⁺/CD44⁺/CD71⁺/HLA-I⁺/HLA-DR⁺/HLA-DQ⁺	Viksman, 1997
	AMs: CD14^dim/reduced CD16⁺/IL10R⁺	Moniuszko, 2007
	PBMs: increased CD14^bright/CD16⁺/CD163⁺	Moniuszko, 2007

Rheumatoid arthritis	PBMs: increased CD14^dim/CD16⁺/HCgp-39⁺	Baeten, 2000
	SynMacs: increased CD14^dim/CD16⁺	Ziegler-Heitbrock, 1993; Wahl, 1992; Kawanaka, 2002

IBD	PBMs: increased CD14^dim/CD16⁺	Hanai, 2008
	IntMacs: CD14^dim/CD209⁺	Kamada, 2009
	MucMacs: increased CD40⁺	Perminow, 2009

Receptor expression: ‘dim’ = +; ‘bright’ = ++. AMs = Alveolar macrophages; PBMs = peripheral blood monocytes; COPD = chronic obstructive pulmonary disorder; IPF = idiopathic pulmonary fibrosis; CILD = chronic inflammatory lung disease; IBD = inflammatory bowel disease; TAMs = tumor-associated macrophages; SynMacs = synovial fluid macrophages; IntMacs = intestinal lumen macrophages; MucMacs = mucosal macrophages.

Only first author is shown (for full references see www.karger.com/doi/10.1159/000296507.