Table 1.
Gastric histology of Helicobacter pylori-infected mice
| Mouse | Active (0–3) | Chronic (0–3) | No. of TLOs | Intraepithelial lymphocytes | Reactive epithelial changes (0–2)a |
|---|---|---|---|---|---|
| Wt | |||||
| 1 | 0 | 1 | 2 | − | 1 |
| 2 | 0 | 1 | 0 | − | 1 |
| 3 | 1 | 1 | 2 | − | 2 |
| 4 | 2 | 2 | 3 | − | 2 |
| 5 | 2 | 2 | 3 | − | 2 |
| 6 | 2 | 2 | 3 | + | 2 |
| 7 | 2 | 2 | 5–6b | + | 2 |
| 8 | 2 | 1 | 2 | + | 2 |
| 9 | 2 | 1 | 1 | + | 2 |
| 10 | 2 | 1 | 3 | + | 2 |
| 11 | 3 | 1 | 1 | + | 2 |
| 12 | 1 | 1 | 0 | − | 1 |
| CXCR5−/− | |||||
| 1 | 0 | 1 | 0 | − | 1 |
| 2 | 1 | 1 | 0 | − | 1 |
| 3 | 0 | 1 | 0 | − | 0 |
| 4 | 2 | 1 | 0 | − | 1 |
| 5 | 1 | 1 | 0 | − | 1 |
| 6 | 0 | 1 | 0 | − | 1 |
| 7 | 2 | 2 | 1c | + | 2 |
| 8 | 0 | 0 | 0 | − | 0 |
| 9 | 0 | 1 | 0 | − | 1 |
| 10 | 3 | 2 | 1c | + | 2 |
| 11 | 0 | 1 | 0 | − | 2 |
| 12 | 0 | 1 | 0 | − | 2 |
| 13 | 0 | 1 | 0 | − | 2 |
| Significance | * | NS | ** | NS | * |
0 = absent, 1 = mild, 2 = moderate, 3 = marked
− normal lymphocytic infiltration, + enhanced lymphocytic infiltrates (>25 IEL/100 epithelial cells), NS nonsignificant
*P < 0.05 (indicates statistical significance); **P < 0.01 (indicates statistical significance)
a0, no changes; 1, epithelial regeneration or epithelial hyperplasia; 2, epithelial regeneration + epithelial hyperplasia
bSLOs plus GC
cUnorganized lymphoid aggregate