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. Author manuscript; available in PMC: 2011 Oct 13.
Published in final edited form as: Structure. 2010 Oct 13;18(10):1300–1310. doi: 10.1016/j.str.2010.07.008

Figure 1.

Figure 1

Schema of the pyruvate carboxylase arrangement and function. (A) Chemical reactions carried out by PC. (B) Domain composition of the pyruvate carboxylase monomer: the biotin carboxylase (BC) domain in red, the protein tetramerization (PT) domain in orange, the carboxyl transferase (CT) domain in green and the biotin carboxyl carrier protein (BCCP) in blue. (C) A side view of the two layers of dimers comprising the homotetramer. (D) Model for the sequential chemical reactions: the biotin linked to the BCCP (in white) is carboxylated in the BC domain of its own monomer, and the transfer of the carboxyl group to pyruvate produces oxaloacetate in the CT domain of the opposite monomer.