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. Author manuscript; available in PMC: 2010 Oct 17.
Published in final edited form as: Gastroenterology. 2008 Jul 9;135(3):989–997. doi: 10.1053/j.gastro.2008.05.078

Fig. 3.

Fig. 3

Hepatocyte-activated CD8 T cells exhibit defects in cytotoxicity and cytokine production. A) 106 DesRAG T cells were adoptively transferred into Met-Kb, Alb-Kb or B10.BR mice and an in vivo CTL assay was performed at day 4. Histograms (left panel) displayed are gated on CFSE+PI− lymphocytes within samples. Results displayed in the right panel represent the means of triplicate samples ± S.E.M in 3 independent experiments. B) and C) CFSE-labeled DesRAG T cells were injected into the tail veins of B10.BR or Met-Kb mice. After 2 days, livers and LN were harvested, lymphocytes isolated, stimulated ex vivo, stained and analyzed for intracellular IFN-γ (B) or intracellular IL-2 (C) by flow cytometry. Histograms are representative of 3 individual experiments performed in triplicate and gated on CFSE+CD8+ cells in all samples.