Figure 6. Left ventricle fibrosis was attenuated in females versus males following MI.
(A) Left ventricular (LV) fibrosis was measured 60 days following MI (small infarcts) in LV sections from male and female hearts stained with Masson’s Trichrome. Scale bar = 1 mm. LV interstitial fibrosis is shown by high magnification in both the remote area (R) and the border-zone (BZ) (B) LV fibrosis was quantified and expressed as the fibrosis area/total area of the whole ventricle or the infarct zone and spared myocardium. Black bars represent males and white bars represent females: the data are presented as mean ± SEM for the number of mice shown. Groups were compared by two-way ANOVA with a Bonferonni post-test to determine the contribution of sex or surgery.